Shopping on line can be easy, simple and save you lots of money. It can also take a lot of your time, frustrate you, and result in unwanted purchases. Now the same can be said for regular high street shopping, but with the vast opportunity presented by the Internet it will pay you to spend a few minutes reading this and understanding how to better optimize your Diuretic shopping experience:
1. Compare - without doubt the biggest advantage that the Diuretic offers shoppers today is the ability to compare thousands of Diuretic at a time. This is a great thing, but not necessarily all the time! Too much can be daunting at times so take advantage of the great comparison sites and where possible let them do the hard work for you.
2. Research - if it has been said it will be on the internet. Ignorance is no longer a justifiable reason for buying the wrong thing. Take the time to research in detail everything that you could possible want to know about
3. Testimonials - don't know anybody that has bought a Diuretic? Wrong! If the Diuretic is good the internet will let you know. Use the Internet as a friend and get testimonials before you buy.
4. Questions - Got a question about Diuretic then search the Forums, FAQ's, Blogs etc. Don't be afraid to ask .....
5. Reputation - Never heard of the company selling Diuretic? Don't worry, no reason why you should know every company in the world, but you know someone that does! Use the internet to find out what people are saying about Diuretic and build up a picture of their reputation for sales, returns, customer service, delivery etc.
6. Returns - still worried that even after all of the above your Diuretic wont be what you want? Check out the returns policy. There is so much competition now that someone, somewhere is bound to offer the terms that you are comfortable with.
7. Feedback - happy with your Diuretic then let people know, after all you are depending on others people input in your buying decision, so why not give a little back.
8. Security - check for the yellow padlock on the Diuretic site before you buy, and the s after http:/ /i.e. https:// = a secure site
9. Contact - got a question about Diuretic, or want to leave a comment then check out the sites contact page. Reputable companies have them and respond.
10. Payment - ready to pay for your Diuretic, then use your credit card or PayPal! Be aware of companies that don't accept them, there may be genuine reasons but given the huge amount of choice you have when buying online there is no reason at all not to buy via credit card or PayPal.
A
diuretic is any
drug that elevates the rate of bodily
stool excretion (diuresis). There are several categories of diuretics. All diuretics increase the excretion of waste from the body, although each class of diuretic does so in a distinct way.
High ceiling loop diuretics
Drugs such as furosemide inhibit the body's ability to reabsorb sodium at the ascending loop in the kidney which leads to a retention of water in the urine as water normally follows sodium back into the extracellular fluid (ECF.) Other examples of high ceiling loop diuretics include ethacrynic acid, torasemide and
bumetanide.
Thiazides
Drugs such as hydrochlorothiazide act on the distal tubule and inhibit the Na-Cl Cotransporter leading to a retention of water in the urine as water normally follows penetrating solutes.
Potassium sparing diuretics
Drugs such as spironolactone are
competitive antagonists of aldosterone.
Aldosterone normally adds sodium channels in the principal cells of the collecting duct and late distal tubule of the nephron. Spironolactone prevents aldosterone from entering the principal cells, preventing sodium reabsorption. Other examples of potassium-sparing diuretics are amiloride and triamterine. These drugs bind to the sodium channels of the principal cells, inhibiting an aldosterone-induced increase in sodium reabsorption.
Osmotic diuretics
Compounds such as mannitol are filtered in the
glomerulus, but cannot be reabsorbed. Their presence leads to an increase in the osmolarity of the filtrate. To maintain osmotic balance, water is retained in the urine.
High Blood Glucose
Glucose, like mannitol, is a sugar that can behave as an osmotic diuretic. Unlike mannitol, glucose is commonly found in the blood. However, in certain conditions such as
diabetes mellitus, the concentration of glucose in the blood exceeds the maximum resorption capacity of the kidney. When this happens, glucose remains in the filtrate, leading to the osmotic retention of water in the urine. Use of some drugs, especially
stimulants may also increase blood glucose and thus increase urination.
Uses
In medicine, diuretics are used to treat heart failure, liver cirrhosis,
hypertension and certain kidney diseases. Some diuretics, such as
acetazolamide, help to make the
urine more
alkaline and are helpful in increasing excretion of substances such as
aspirin in cases of
drug overdose or poisoning. Diuretics are often abused by sufferers of eating disorders, especially bulimics, in attempts at weight loss.
The antihypertensive actions of some diuretics (thiazides and loop diuretics in particular) are independent of their diuretic effect. That is, the reduction in blood pressure is not due to decreased blood volume resulting from increased urine production, but occurs through other mechanisms and at lower doses than that required to produce diuresis. Indapamide was specifically designed with this in mind, and has a larger therapeutic window for hypertension (without pronounced diuresis) than most other diuretics.
Mechanism of action
{| border="1" cellpadding="1" cellspacing="1" style="border-collapse: collapse; margin: 0 0 0 0.5em"! colspan="4" bgcolor="#eeeeee" | Classification of common diuretics and their mechanisms of action|- align="center" style="border-bottom: 3px solid gray"! bgcolor="#eeeeee" | Agent Group! Examples! bgcolor="#ddeeff" | Mechanism! Location|-| bgcolor="#eeeeee" |
-| Ethanol,
Water secretion|-| bgcolor="#eeeeee" | Acidifying [salts] antagonists| amphotericin B, lithium citrate ]|-| bgcolor="#eeeeee" |
Aquaretics],
Juniper| [acetazolamide,
dorzolamide|-| bgcolor="#eeeeee" | [Loop diuretics],
ethacrynic acid,
furosemide,
torsemide| medullary [thick ascending limb diuretics| [glucose (especially in uncontrolled diabetes), mannitol, [Descending limb of loop of Henle|-| bgcolor="#eeeeee" |
Potassium-sparing diuretics], spironolactone,
triamterene exchange: Spironolactone inhibits [aldosterone action, Amiloride inhibits
epithelial sodium channels]|-| bgcolor="#eeeeee" |
Thiazides], hydrochlorothiazide reabsorption| [distal convoluted tubuless| [caffeine,
theophylline| tubules|-|}
Chemically, diuretics are a diverse group of compounds that either stimulate or inhibit various [hormones that naturally occur in the body to regulate urine production by the kidneys. Herbs are not inherently diuretics. They are more correctly called
aquaretics.
External links
- Diagram at mmi.mcgill.ca
- Diagram at cvpharmacology.com
A
diuretic is any drug that elevates the rate of bodily stool excretion (diuresis). There are several categories of diuretics. All diuretics increase the excretion of waste from the body, although each class of diuretic does so in a distinct way.
High ceiling loop diuretics
Drugs such as
furosemide inhibit the body's ability to reabsorb
sodium at the ascending loop in the kidney which leads to a retention of water in the urine as water normally follows sodium back into the extracellular fluid (ECF.) Other examples of high ceiling loop diuretics include
ethacrynic acid,
torasemide and bumetanide.
Thiazides
Drugs such as
hydrochlorothiazide act on the distal tubule and inhibit the Na-Cl Cotransporter leading to a retention of water in the urine as water normally follows penetrating solutes.
Potassium sparing diuretics
Drugs such as
spironolactone are
competitive antagonists of aldosterone.
Aldosterone normally adds sodium channels in the principal cells of the collecting duct and late distal tubule of the nephron. Spironolactone prevents aldosterone from entering the principal cells, preventing sodium reabsorption. Other examples of potassium-sparing diuretics are amiloride and triamterine. These drugs bind to the sodium channels of the principal cells, inhibiting an aldosterone-induced increase in sodium reabsorption.
Osmotic diuretics
Compounds such as mannitol are filtered in the glomerulus, but cannot be reabsorbed. Their presence leads to an increase in the osmolarity of the filtrate. To maintain osmotic balance, water is retained in the urine.
High Blood Glucose
Glucose, like mannitol, is a sugar that can behave as an osmotic diuretic. Unlike mannitol, glucose is commonly found in the blood. However, in certain conditions such as
diabetes mellitus, the concentration of glucose in the blood exceeds the maximum resorption capacity of the kidney. When this happens, glucose remains in the filtrate, leading to the osmotic retention of water in the urine. Use of some drugs, especially
stimulants may also increase blood glucose and thus increase urination.
Uses
In
medicine, diuretics are used to treat
heart failure, liver cirrhosis, hypertension and certain
kidney diseases. Some diuretics, such as
acetazolamide, help to make the
urine more
alkaline and are helpful in increasing excretion of substances such as aspirin in cases of drug overdose or poisoning. Diuretics are often abused by sufferers of eating disorders, especially bulimics, in attempts at weight loss.
The antihypertensive actions of some diuretics (
thiazides and
loop diuretics in particular) are independent of their diuretic effect. That is, the reduction in blood pressure is not due to decreased blood volume resulting from increased urine production, but occurs through other mechanisms and at lower doses than that required to produce diuresis. Indapamide was specifically designed with this in mind, and has a larger therapeutic window for hypertension (without pronounced diuresis) than most other diuretics.
Mechanism of action
{| border="1" cellpadding="1" cellspacing="1" style="border-collapse: collapse; margin: 0 0 0 0.5em"! colspan="4" bgcolor="#eeeeee" | Classification of common diuretics and their mechanisms of action|- align="center" style="border-bottom: 3px solid gray"! bgcolor="#eeeeee" | Agent Group! Examples! bgcolor="#ddeeff" | Mechanism! Location|-| bgcolor="#eeeeee" |
-| Ethanol,
Water secretion|-| bgcolor="#eeeeee" | Acidifying [salts] antagonists|
amphotericin B, lithium citrate ]|-| bgcolor="#eeeeee" |
Aquaretics],
Juniper| [acetazolamide, dorzolamide|-| bgcolor="#eeeeee" |
[Loop diuretics],
ethacrynic acid,
furosemide,
torsemide| medullary [thick ascending limb diuretics| [glucose (especially in uncontrolled diabetes),
mannitol, [Descending limb of loop of Henle|-| bgcolor="#eeeeee" |
Potassium-sparing diuretics], spironolactone,
triamterene exchange: Spironolactone inhibits [aldosterone action, Amiloride inhibits epithelial sodium channels]|-| bgcolor="#eeeeee" |
Thiazides],
hydrochlorothiazide reabsorption| [distal convoluted tubuless| [caffeine, theophylline| tubules|-|}
Chemically, diuretics are a diverse group of compounds that either stimulate or inhibit various [hormones that naturally occur in the body to regulate urine production by the kidneys. Herbs are not inherently diuretics. They are more correctly called
aquaretics.
External links
- Diagram at mmi.mcgill.ca
- Diagram at cvpharmacology.com
Diuretic - Wikipedia, the free encyclopedia
A diuretic is any drug that elevates the rate of urination (diuresis). There are several categories of diuretics. All diuretics increase the excretion of water from the body ...
Definition: diuretic from Online Medical Dictionary
The Online Medical Dictionary is a searchable dictionary of definitions from medicine, science and technology.
diuretic
diuretic. diuretic - Medicine Guide. diuretic: This is a type of medicine that increases urine production by removing fluid from the body. It is used to treat hypertension and ...
Herbal diuretic for oedema herbal water pills fluid retention product
herbal water pills odema water retention herbs - fluid retention drug free supplements with parsley, alfalfa & horsetail! Herbal combination for water retention oedema. water ...
Diuretics & side-effects of diuretic medicines
Bupa health factsheet - often used to treat high blood pressure, diuretics are medicines that remove water from the body by increasing the amount of urine the kidneys produce
Diuretic - definition of Diuretic in the Medical dictionary - by the ...
diuretic /di·uret·ic/ (di?u-ret´ik) 1. pertaining to or causing diuresis. 2. an agent that promotes diuresis. high-ceiling diuretics , loop diuretics those exerting their ...
Side effects of triamterene diuretic - Pills Info™
Side effects of triamterene diuretic - Pills Info™ ... Of elevated blood pressure and swelling due to excess body water. Further side effects of triamterene diuretic information ...
diuretic - definition of diuretic by the Free Online Dictionary ...
di·u·ret·ic (d-r t k) adj. Tending to increase the discharge of urine. n. A substance or drug that tends to increase the discharge of urine. [Middle English diuretik, from ...
diuretic definition |Dictionary.com
Hypertension Causes Tips to Understand & Monitor High Blood Pressure - Make Changes Today www.COREGCR.com
diuretic definition |Dictionary.com
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